A mutation in telethonin alters Nav1.5 function. VOLUME 283 (2008) PAGES 16537-16544

Limb-girdle muscular dystrophy in a Portuguese patient caused by a mutation in the telethonin gene.

Limb-girdle muscular dystrophy 2G is caused by mutations in the telethonin (TCAP) gene in chromosome 17q11-12. This rare form of hereditary muscle disease was originally described in Brazilian patients and was recently identified in Chinese and Moldavian patients. We present the first Portuguese patient with a limb-girdle muscular dystrophy caused by a mutation in the TCAP gene. A Caucasian mal...

SWP Comments 2008/C 01, February 2008, 4 pages

Alongside their NATO allies German troops are facing a growing insurgency in Afghanistan. However, the alliance still lacks a joint strategy to deal with this challenge. While the US government recently called on NATO to pursue a “classical” counterinsurgency campaign, Germany insisted on the development of a more “comprehensive strategy” before the next Summit in Bucharest in April 2008. Yet, ...

Volume contents (e-only pages)

Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation 3 FGF signalling controls expression of vomeronasal receptors during embryogenesis 17 V.T. Cunliffe, P. Casaccia-Bonnefil (UK, USA) Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS 24 FGF signaling is necessary for ...

Volume Contents (E-only pages)

Volume Contents (E-only pages)

Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas 15 Ce-Y14 and MAG-1, components of the exon–exon junction complex, are required for embryogenesis and germline sexual switching in Caenorhabditis elegans 27 The grainy head transcription factor is essential for the function of the frizzled pathway in the Drosophila wing 37 The MADS-box transcription...